Tailoring of silica nanoarchitecture to optimize Cu(2􀀀 x)S based image-guided chemodynamic therapy agent

Tailoring of silica nanoarchitecture to optimize Cu(2􀀀 x)S based
image-guided chemodynamic therapy agent

Svetlana Fedorenko a,*, Alexey Stepanov a, Olga Bochkova a,b, Kirill Kholin c, Alexey Dovjenko b,
Rustem Zairov a, Irek Nizameev a, Tatiana Gerasimova a, Igor Strelnik a, Alexandra Voloshina a,
Anastasia Sapunova a, Syumbelya Gumerova a, Aidar Gubaidullin a, Svetlana Fedosimova b,
Vladimir Evtugyn b, Asiya Toropchina a, Andrey Karasik a, Asiya Mustafina a
a Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str., 8, 420088 Kazan, Russian Federation
b Kazan (Volga region) Federal University, 18 Kremlyovskaya str., 420008 Kazan, Russian Federation
c Kazan National Research Technical University named after A.N. Tupolev - KAI, 10, K. Marx str., Kazan 420111, Russian Federation
H I G H L I G H T S G R A P H I C A L A B S T R A C T
• Optimal architecture of silica coated
Cu(2􀀀 x)S nanoparticles for high ROS
generation.
• Red or green emitting Cu(2􀀀 x)S nanoparticles
for visualization of cellular
uptake.
• Surface exposure of Cu(2􀀀 x)S facilitates
ROS generation.
• Surface decoration by CDs for nuclear
localization of Cu(2􀀀 x)S nanoparticles.
• Nuclear localization of Cu(2􀀀 x)S nanoparticles
enhances CDT treating of cancer
cells.